Inclusion bodies are insoluble aggregates of misfolded proteins inside the cell. A common pathogenic event in a range of neurodegenerative illnesses is aggregated proteins from the cytoplasm of nerve cells and glia.
Examples
P62 inclusion
Formation, Composition & dynamics (Assembly and disassembly)
Relation to human diseases
Proteome
Tau inclusion
Formation, Composition & dynamics (Assembly and disassembly)
Relation to human diseases
Proteome
Htt inclusion
Formation, Composition & dynamics (Assembly and disassembly)
Relation to human diseases
Proteome
(Further detail:23912309, 25447870, 30341583, 32096047).
References
Richter-Landsberg C, Leyk J. Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration. Acta Neuropathol. 2013 Dec;126(6):793-807. doi: 10.1007/s00401-013-1158-x. Epub 2013 Aug 3. PMID: 23912309.
Singh A, Upadhyay V, Panda AK. Solubilization and refolding of inclusion body proteins. Methods Mol Biol. 2015;1258:283-91. doi: 10.1007/978-1-4939-2205-5_15. PMID: 25447870.
Humer D, Spadiut O. Wanted: more monitoring and control during inclusion body processing. World J Microbiol Biotechnol. 2018 Oct 19;34(11):158. doi: 10.1007/s11274-018-2541-5. PMID: 30341583; PMCID: PMC6208753.
Kosik KS, Han S. Tau Condensates. Adv Exp Med Biol. 2019;1184:327-339. doi: 10.1007/978-981-32-9358-8_24. PMID: 32096047.