Anisosomes are nuclear liquid spherical shells with liquid core formed by demixing of RNA-binding deficient TDP-43 protein molecules. Formation of anisosome droplets represent a liquid crystal formation and is important in age related neurodegenerative diseases (33335017).
Formation, Composition & dynamics (Assembly and disassembly)
Relation to human diseases
Proteome
References
Yu H, Lu S, Gasior K, Singh D, Vazquez-Sanchez S, Tapia O, Toprani D, Beccari MS, Yates JR 3rd, Da Cruz S, Newby JM, Lafarga M, Gladfelter AS, Villa E, Cleveland DW. HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. Science. 2021 Feb 5;371(6529):eabb4309. doi: 10.1126/science.abb4309. Epub 2020 Dec 17. PMID: 33335017; PMCID: PMC8286096.